INVESTIGATING THE GUT MICROBIOME USING SIMPLE FERMENTATION EXPERIMENTS
Zenith College of Advanced Sciences, India
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The human gut microbiome is a complex community of microorganisms that plays a pivotal role in host metabolism, immunity, and overall health. While high-throughput sequencing and multi-omics approaches have advanced understanding significantly, simple fermentation experiments—especially in vitro batch and continuous culture systems—remain essential tools for modeling microbial interactions, elucidating metabolic pathways, and testing dietary effects on microbial dynamics. This research article investigates fundamental principles of gut microbiome ecology by applying controlled fermentation experiments under laboratory conditions. Through manipulating substrates (e.g., dietary fibers, prebiotics), environmental parameters (pH, anaerobiosis), and host-associated factors (bile acids), we demonstrate how microbial communities respond functionally and compositionally. Results reveal distinct fermentation profiles correlated with substrate complexity, with short-chain fatty acid (SCFA) production and microbial shifts reflecting metabolic capabilities of key taxa. The study underscores the utility of simple fermentation models for hypothesis testing and educational purposes, while acknowledging limitations relative to in vivo systems. Findings have implications for designing targeted dietary interventions and understanding basic microbial ecology within the gut.
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Nair, M. V. & Choudhary, A. A. (2026). Investigating the Gut Microbiome Using Simple Fermentation Experiments. International Journal of Science, Strategic Management and Technology, 02(02), 1-9. https://doi.org/10.55041/ijsmt.v2i2.002
Nair, Meera, and Ankit Choudhary. "Investigating the Gut Microbiome Using Simple Fermentation Experiments." International Journal of Science, Strategic Management and Technology, vol. 02, no. 02, 2026, pp. 1-9. doi:https://doi.org/10.55041/ijsmt.v2i2.002.
Nair, Meera, and Ankit Choudhary. "Investigating the Gut Microbiome Using Simple Fermentation Experiments." International Journal of Science, Strategic Management and Technology 02, no. 02 (2026): 1-9. https://doi.org/https://doi.org/10.55041/ijsmt.v2i2.002.
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