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International Journal of Science, Strategic Management and Technology

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ISSN: 3108-1762 (Online)
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EXTRACTION AND CHARACTERIZATION OF THERAPEUTIC POTENTIAL OF THE INK AND TISSUE EXTRACT OF DORYTEUTHIS SINGHALENSIS FROM THE GULF OF MANNAR

AUTHORS:
S. Mohamatha Zuwairiya
Mentor
M. Velankanny
Affiliation
CC BY 4.0 License:
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract

The marine environment is a rich source of unique bioactive compounds with promising pharmaceutical potential. Cephalopods, particularly cuttlefish, produce biologically active substances in their tissues and ink that may serve as novel antimicrobial agents. The present study investigates the antimicrobial properties of crude ink and tissue extracts of Doryteuthis singhalensis against selected pathogenic bacterial strains. Extraction was performed using polar and non-polar solvents, followed by antimicrobial assays, SDS-PAGE protein profiling, and GC-MS analysis to characterize the bioactive constituents. Results revealed significant antibacterial activity, particularly in methanolic extracts and identified several bioactive compounds, including carveol, phenolic derivatives, steroids and astaxanthin. These findings highlight the potential of cuttlefish-derived compounds as candidates for novel antimicrobial drug development.

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Zuwairiya, S. M. (2026). Extraction and Characterization of Therapeutic Potential of the Ink and Tissue Extract of Doryteuthis Singhalensis from the Gulf of Mannar. International Journal of Science, Strategic Management and Technology, 02(04). https://doi.org/10.55041/ijsmt.v2i4.411

Zuwairiya, S.. "Extraction and Characterization of Therapeutic Potential of the Ink and Tissue Extract of Doryteuthis Singhalensis from the Gulf of Mannar." International Journal of Science, Strategic Management and Technology, vol. 02, no. 04, 2026, pp. . doi:https://doi.org/10.55041/ijsmt.v2i4.411.

Zuwairiya, S.. "Extraction and Characterization of Therapeutic Potential of the Ink and Tissue Extract of Doryteuthis Singhalensis from the Gulf of Mannar." International Journal of Science, Strategic Management and Technology 02, no. 04 (2026). https://doi.org/https://doi.org/10.55041/ijsmt.v2i4.411.

References
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2.Atta and  Ahmed M., 2021. Antimicrobial properties of cephalopod ink from Sepia officinalis against pathogenic bacteria.

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4.Bansemir, Anne, Blume, Marie, Schröder, Stefan and  Lindequist, Ulf. 2006. Screening of cultivated seaweeds for antibacterial activity against fish pathogenic bacteria. Aquaculture, 252(1), 79–84.

5.Blunt, J. W., Carroll, A. R., Copp, B. R., Davis, R. A., Keyzers, R. A., and Prinsep, M. R. 2023. Marine natural products. Natural Product Reports, 40, 1–80 https://doi.org/10.1039/D2NP00090H

6.Blunt, J. W., Carroll, A. R., Copp, B. R., Davis, R. A., Keyzers, R. A., and Prinsep, M. R. 2018.  Marine natural products. Natural Product Reports, 35, 8–53.

7.Boscaro, R.L., 2005. An observation of inking behavior protecting adult Octopus bocki from predation by a green turtle (Chelonia mydas) hatchling. Pac. Sci. 59: 69-72.

8.Boscaro, V., Holt, CC., Van Steenkiste, NWL., Herranz, M., Irwin, NAT., Alvarez-Campos, P., Grzelak, K., Holovachov, O., Kerbl, A., Mathur, V., Okamoto, N., Piercey, RS., Worsaae, K., Leander, BS., Keeling, PJ., 2022. Microbiomes of microscopic marine invertebrates do not reveal signatures of phylosymbiosis, Natural Microbiol, PP., 7:810 - 819.
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This article has undergone plagiarism screening and double-blind peer review. Editorial policies have been followed. Authors retain copyright under CC BY-NC 4.0 license. The research complies with ethical standards and institutional guidelines.
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