ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF HERBAL EXTRACT IN STREPTOZOTOCIN-INDUCED MODEL
Department of Pharmaceutics,
Apex College of Pharmaceutical Sciences, India
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Diabetes mellitus (DM) is a prevalent metabolic disorder characterized by chronic hyperglycemia and dyslipidemia, leading to severe complications such as cardiovascular disease, nephropathy, and neuropathy. Streptozotocin (STZ)-induced diabetic animal models are widely used to evaluate the therapeutic potential of herbal agents due to their ability to produce reproducible hyperglycemia and lipid abnormalities similar to type 2 diabetes. In recent years, numerous herbal extracts have been investigated for antidiabetic and antihyperlipidemic activities in STZ-induced models, demonstrating reductions in blood glucose, improvements in lipid profiles, and protective effects on key organs. This review consolidates the scientific evidence supporting the efficacy of botanical extracts and polyherbal formulations, explores their mechanisms of action, and provides a framework for future research.
Key findings: • Herbal extracts like Kigelia pinnata, Artemisia indica, Piper longum, Spondias mombin, and various polyherbal preparations have shown significant reductions in blood glucose levels and improvements in lipid profiles in STZ-induced diabetic rats.
Conclusion: Herbal extracts exhibit promising antidiabetic and antihyperlipidemic effects in STZ-induced models, suggesting potential as complementary or alternative therapeutics for DM management. Standardization, mechanism exploration, and clinical trials are needed to translate these findings into effective human therapy.
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Sharma, R. K. (2026). Antidiabetic and Antihyperlipidemic Activity of Herbal Extract in Streptozotocin-Induced Model. International Journal of Science, Strategic Management and Technology, 02(01), 1-9. https://doi.org/10.55041/ijsmt.v2i1.003
Sharma, Rohit. "Antidiabetic and Antihyperlipidemic Activity of Herbal Extract in Streptozotocin-Induced Model." International Journal of Science, Strategic Management and Technology, vol. 02, no. 01, 2026, pp. 1-9. doi:https://doi.org/10.55041/ijsmt.v2i1.003.
Sharma, Rohit. "Antidiabetic and Antihyperlipidemic Activity of Herbal Extract in Streptozotocin-Induced Model." International Journal of Science, Strategic Management and Technology 02, no. 01 (2026): 1-9. https://doi.org/https://doi.org/10.55041/ijsmt.v2i1.003.
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