Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated (Cas) systems represent a transformative suite of gene editing technologies that have revolutionized modern biology. CRISPR–Cas systems provide unprecedented precision, efficiency, and flexibility for editing genomes across diverse organisms. Their applications span medicine, agriculture, biotechnology, and environmental science. However, CRISPR’s rapid development has generated complex ethical, legal, and social considerations that demand thoughtful debate and policy development. This research article provides a foundational overview of CRISPR mechanisms and explores ethical discussions in gene editing, including human, agricultural, and ecological implications. A novel contribution is the integration of simulated gene editing models—frameworks that allow ethical scenario analysis without direct experimentation on organisms. Simulated models serve as valuable tools for education, policy assessment, and risk forecasting. Through literature review, method development, and results from ethical simulation scenarios, this article elucidates how theoretical modeling can inform responsible CRISPR applications. The discussion highlights key ethical frameworks, conflict areas, and strategies for governance. Overall, integrating CRISPR basics with ethical simulation modeling supports informed decision-making and responsible innovation in genomics.These models enable researchers and policymakers to simulate potential outcomes and ethical dilemmas associated with gene editing interventions before implementation. By providing a controlled environment for exploring hypothetical scenarios, simulated gene editing models help mitigate risks and foster transparent dialogue among stakeholders. This approach facilitates the development of balanced policies that align scientific innovation with societal values and ethical standards.