The present study investigated the effect of a structured six-week yoga training program on eye-hand coordination ability and reaction time ability among male graduation students. A total of sixty physical education students (aged 22–28 years) from Kuvempu University were randomly assigned into two equal groups: an experimental group (N=30) and a control group (N=30). The experimental group underwent a structured yoga intervention consisting of Asanas, Pranayama, and Kriyas for 60 minutes per session, three days per week (Monday, Wednesday, and Friday) across six weeks. The control group maintained their regular routine without participating in any specialized training. Pre- and post-tests were administered using a standardized Mirror-Tracing Task test to measure eye-hand coordination (assessing timing and errors) and an Audio/Visual Reaction Time test device to measure reaction time in milliseconds. Data were analyzed using descriptive statistics and paired samples t-tests at a 0.05 level of confidence. The results revealed significant intra-group improvements within the experimental group from pre-test to post-test for right hand eye-hand coordination (t = 6.496, p < 0.05), left hand eye-hand coordination (t = 5.800, p < 0.05), and reaction time (t = 17.162, p < 0.05). In contrast, the control group exhibited no significant changes across all variables. However, inter-group comparative post-test t-scores indicated no statistically significant difference between the experimental and control groups at the post-test stage. The findings suggest that while a short term six-week customized yoga program effectively enhances personal psychomotor and neuromuscular functioning, an extended intervention with higher intensity or specialized proprioceptive training may be required to establish dominant inter-group performance superiority.