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International Journal of Science, Strategic Management and Technology

An International, Peer-Reviewed, Open Access Scholarly Journal Indexed in recognized academic databases · DOI via Crossref The journal adheres to established scholarly publishing, peer-review, and research ethics guidelines set by the UGC

ISSN: 3108-1762 (Online)
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FORMULATION AND EVALUATION OF HERBAL-BASED ANTI-ACNE CREAM

AUTHORS:
Amit Sihmar
Jatin tyagi
Saptrishi
Kunal
Mentor
Affiliation
CC BY 4.0 License:
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract

Acne vulgaris is one of the most prevalent dermatological conditions worldwide, affecting approximately 85% of individuals between 12 and 24 years of age. Growing consumer preference for natural, plant-based therapies has driven renewed scientific interest in herbal anti-acne formulations. This review comprehensively examines the pathophysiology of acne, the pharmacological rationale for using herbal ingredients, the methodologies employed in cream formulation, and the evaluation parameters used to assess safety and efficacy. Key herbal actives reviewed include neem (Azadirachta indica), tea tree oil (Melaleuca alternifolia), turmeric (Curcuma longa), aloe vera (Aloe barbadensis), green tea (Camellia sinensis), witch hazel, licorice, and calendula. Published results consistently demonstrate that herbal anti-acne creams exhibit significant antimicrobial activity against Propionibacterium acnes, favorable physicochemical profiles (pH 4.5–6.5, appropriate viscosity and spreadability), and acceptable safety in patch tests. The review concludes that herbal-based anti-acne creams represent a promising, well-tolerated alternative to conventional synthetic preparations.

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Sihmar, A., tyagi, J., Saptrishi, & Kunal, (2026). Formulation and Evaluation of Herbal-Based Anti-ACNE Cream. International Journal of Science, Strategic Management and Technology, 02(04). https://doi.org/10.55041/ijsmt.v2i4.361

Sihmar, Amit, et al.. "Formulation and Evaluation of Herbal-Based Anti-ACNE Cream." International Journal of Science, Strategic Management and Technology, vol. 02, no. 04, 2026, pp. . doi:https://doi.org/10.55041/ijsmt.v2i4.361.

Sihmar, Amit,Jatin tyagi, Saptrishi, and Kunal. "Formulation and Evaluation of Herbal-Based Anti-ACNE Cream." International Journal of Science, Strategic Management and Technology 02, no. 04 (2026). https://doi.org/https://doi.org/10.55041/ijsmt.v2i4.361.

References
1.Bassett IB, Pannowitz DL, Barnetson RS. A comparative study of tea-tree oil versus benzoyl peroxide in the treatment of acne. Med J Aust. 1990;153(8):455-458.

2.Diksha S, Priyanka R, et al. Formulation and evaluation of polyherbal anti-acne cream containing neem, aloe vera and turmeric. Int J Pharm Sci Res. 2021;12(5):2645-2653.

3.Jain S, Sharma A, et al. Tea tree oil versus green tea extract in anti-acne topical preparations. J Clin Cosmet Dermatol. 2020;4(1):19-25.

4.Sharma R, Gupta V. Formulation and evaluation of a novel polyherbal anti-acne cream. Asian J Pharm Clin Res. 2022;15(3):112-118.

5.Patel A, Singh N, et al. Anti-acne and skin-brightening effects of licorice-turmeric cream: a randomized comparative trial. Phytother Res. 2019;33(10):2760-2769.

6.Kumar S, Aggarwal M, et al. Development and evaluation of a neem-clove anti-acne formulation with enhanced antibacterial activity. J Drug Deliv Sci Technol. 2023;80:104149.

7.Bhatt N, Shah D, et al. Aloe vera and papaya enzyme cream: cosmeceutical anti-acne application. J Herb Med Pharmacol. 2020;9(4):340-347.

8.Mishra P, Tiwari A, et al. Design optimization of polyherbal anti-acne cream using Box-Behnken design. Indian J Pharm Sci. 2021;83(2):344-356.

9.Zouboulis CC, Jourdan E, Picardo M. Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions. J Eur Acad Dermatol Venereol. 2014;28(5):527-532.

10.ICH Q1A(R2). Stability Testing of New Drug Substances and Products. International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use; 2003.
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This article has undergone plagiarism screening and double-blind peer review. Editorial policies have been followed. Authors retain copyright under CC BY-NC 4.0 license. The research complies with ethical standards and institutional guidelines.
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