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International Journal of Science, Strategic Management and Technology

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ISSN: 3108-1762 (Online)
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GREEN SYNTHESIS OF NANOPARTICLES USING PLANT EXTRACT AND THEIR PHARMACOLOGICAL SCREENING

AUTHORS:
Sneha P. Kulkarni
Aarav K. Mishra
Mentor
Prof. Meera V. Nair
Affiliation

Department of Environmental Science,
Dr. A.P.J. Institute of Science & Innovation, India

CC BY 4.0 License:
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract

Nanotechnology has emerged as a transformative field with wide-ranging applications in medicine, agriculture, environmental science, and industry. Among its various branches, the synthesis of nanoparticles (NPs) using environmentally benign methods has attracted significant attention in recent years. Green synthesis, particularly employing plant extracts, offers an eco-friendly, cost-effective, and sustainable alternative to conventional physical and chemical synthesis methods, which often involve toxic reagents and high energy consumption. Plant-mediated synthesis utilizes phytochemicals such as flavonoids, phenolics, alkaloids, terpenoids, and proteins as reducing, stabilizing, and capping agents, enabling the formation of nanoparticles with controlled size and morphology. This research article comprehensively discusses the principles, mechanisms, and advantages of green synthesis of nanoparticles using plant extracts, with a particular focus on metallic and metal oxide nanoparticles such as silver, gold, zinc oxide, and iron oxide. Furthermore, the pharmacological screening of these green-synthesized nanoparticles is critically reviewed, highlighting their antimicrobial, antioxidant, anti-inflammatory, anticancer, antidiabetic, and wound-healing activities. The article also integrates suggested tables and figures that summarize plant sources, synthesis conditions, characterization techniques, and pharmacological outcomes. Challenges, limitations, and future perspectives of plant-mediated nanoparticle synthesis in pharmaceutical and biomedical applications are also discussed.

Keywords
Green synthesis; Nanoparticles; Plant extract; Phytochemicals; Pharmacological screening; Antimicrobial activity; Nanomedicine
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Kulkarni, S. P. & Mishra, A. K. (2026). Green Synthesis of Nanoparticles Using Plant Extract and Their Pharmacological Screening. International Journal of Science, Strategic Management and Technology, 02(01), 1-9. https://doi.org/10.55041/ijsmt.v2i1.005

Kulkarni, Sneha, and Aarav Mishra. "Green Synthesis of Nanoparticles Using Plant Extract and Their Pharmacological Screening." International Journal of Science, Strategic Management and Technology, vol. 02, no. 01, 2026, pp. 1-9. doi:https://doi.org/10.55041/ijsmt.v2i1.005.

Kulkarni, Sneha, and Aarav Mishra. "Green Synthesis of Nanoparticles Using Plant Extract and Their Pharmacological Screening." International Journal of Science, Strategic Management and Technology 02, no. 01 (2026): 1-9. https://doi.org/https://doi.org/10.55041/ijsmt.v2i1.005.

References

1.               Ahmed S, Ahmad M, Swami BL, Ikram S. Green synthesis of silver nanoparticles using plant extracts. J Adv Res. 2016;7(1):17–28.


2.               Iravani S. Green synthesis of metal nanoparticles using plants. Green Chem. 2011;13:2638–2650.


3.               Rai M, Yadav A, Gade A. Silver nanoparticles as a new generation of antimicrobials. Biotechnol Adv. 2009;27:76–83.


4.               Mittal AK, Chisti Y, Banerjee UC. Synthesis of metallic nanoparticles using plant extracts. Biotechnol Adv. 2013;31:346–356.


5.               Sharma VK, Yngard RA, Lin Y. Silver nanoparticles: Green synthesis and applications. Adv Colloid Interface Sci. 2009;145:83–96.


6.               Kartini, K., Alviani, A., Anjarwati, D., Fanany, A. F., Sukweenadhi, J., & Avanti, C. (2020). Process Optimization for Green Synthesis of Silver Nanoparticles Using Indonesian Medicinal Plant Extracts. Processes, 8(8), 998. https://doi.org/10.3390/pr8080998


7.               Eker, F., Akdaşçi, E., Duman, H., Bechelany, M., & Karav, S. (2025). Green Synthesis of Silver Nanoparticles Using Plant Extracts: A Comprehensive Review of Physicochemical Properties and Multifunctional Applications. International Journal of Molecular Sciences, 26(13), 6222. https://doi.org/10.3390/ijms26136222


8.               Miranda, A., Akpobolokemi, T., Chung, E., Ren, G., & Raimi-Abraham, B. T. (2022). pH Alteration in Plant-Mediated Green Synthesis and Its Resultant Impact on Antimicrobial Properties of Silver Nanoparticles (AgNPs). Antibiotics, 11(11), 1592. https://doi.org/10.3390/antibiotics11111592


9.               Selvam, K., Ragu Prasath, A., & Alanazi, A. K. (2025). A Review of Recent Developments in Green Synthesis of Silver Nanoparticles: Antioxidant and Antibacterial Applications. Microscopy Research and Technique, 89(1), 134–147. https://doi.org/10.1002/jemt.70060


10.            Azad, A., Zafar, H., Raza, F., & Sulaiman, M. (2023). Factors Influencing the Green Synthesis of Metallic Nanoparticles Using Plant Extracts: A Comprehensive Review. Pharmaceutical Fronts, 05(03), e117–e131. https://doi.org/10.1055/s-0043-1774289

Ethics and Compliance
✓ All ethical standards met
This article has undergone plagiarism screening and double-blind peer review. Editorial policies have been followed. Authors retain copyright under CC BY-NC 4.0 license. The research complies with ethical standards and institutional guidelines.
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