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International Journal of Science, Strategic Management and Technology

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PH-DEPENDENT SOLUBILITY AND UV–VISIBLE SPECTROPHOTOMETRIC ANALYSIS OF ISOTRETINOIN IN VARIOUS DISSOLUTION MEDIA

AUTHORS:
Fiza Mansoor Bhaldar
Sakshi Dhananjay Kuchekar
Tushar Ramesh Pukale
Mentor
Affiliation
Rajarambapu College of Pharmacy, Kasegaon, Sangli.
DOI: 10.55041/ijsmt.v2i5.123
CC BY 4.0 License:
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Abstract

Solubility is an important factor influencing the oral bioavailability of poorly water-soluble drugs such as isotretinoin. In this study, the pH-dependent solubility and spectrophotometric characteristics of isotretinoin were evaluated in different media (pH 1.2, 5.8, 6.8, and 7.4). The λmax was determined using UV–Visible spectroscopy, and calibration curves in all media showed good linearity, confirming the reliability of the method.


Saturated solubility studies revealed that isotretinoin has very low solubility in distilled water and acidic conditions, while its solubility increases as the pH rises. The λmax remained nearly unchanged across all pH conditions, indicating that pH does not significantly affect its absorption properties. The increase in solubility at higher pH is due to greater ionization of the drug.


Overall, the results highlight that isotretinoin exhibits pH-dependent solubility, and optimizing pH conditions is essential in formulation development to enhance its solubility and oral bioavailability, as it belongs to the BCS Class II category.

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PUBLICATION DETAILS
Review Type:
Double-Blind Peer Review
License:
CC BY-NC 4.0
Volume/Issue:
Volume 02, Issue 05
Review Rounds:
2
Article Type:
Research Article
Publication Date:
May 09 2026
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Bhaldar, F. M., Kuchekar, S. D. & Pukale, T. R. (2026). PH-Dependent Solubility and UV–Visible Spectrophotometric Analysis of Isotretinoin in Various Dissolution Media. International Journal of Science, Strategic Management and Technology, 02(05). https://doi.org/10.55041/ijsmt.v2i5.123

Bhaldar, Fiza, et al.. "PH-Dependent Solubility and UV–Visible Spectrophotometric Analysis of Isotretinoin in Various Dissolution Media." International Journal of Science, Strategic Management and Technology, vol. 02, no. 05, 2026, pp. . doi:https://doi.org/10.55041/ijsmt.v2i5.123.

Bhaldar, Fiza,Sakshi Kuchekar, and Tushar Pukale. "PH-Dependent Solubility and UV–Visible Spectrophotometric Analysis of Isotretinoin in Various Dissolution Media." International Journal of Science, Strategic Management and Technology 02, no. 05 (2026). https://doi.org/https://doi.org/10.55041/ijsmt.v2i5.123.

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This article has undergone plagiarism screening and double-blind peer review. Editorial policies have been followed. Authors retain copyright under CC BY-NC 4.0 license. The research complies with ethical standards and institutional guidelines.
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