SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) FOR ENHANCING BIOAVAILABILITY OF BCS CLASS II DRUGS
Apex College of Pharmaceutical Sciences, India
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The Self-Emulsifying Drug Delivery System (SEDDS) represents an advanced lipid-based formulation platform designed to enhance the oral bioavailability of poorly water-soluble drugs, especially those categorized under Biopharmaceutics Classification System (BCS) Class II. BCS Class II drugs exhibit high permeability but low aqueous solubility, resulting in limited dissolution and inconsistent absorption. SEDDS enhance solubility and absorption through spontaneous formation of fine oil-in-water emulsions in the gastrointestinal tract, facilitated by surfactants and co-solvents. This comprehensive review discusses mechanisms of self-emulsification, formulation considerations, key excipients, in vitro characterization techniques, and in vivo performance. Challenges such as drug precipitation, scale-up, and regulatory considerations are evaluated. Case studies of drugs like curcumin, simvastatin, and paclitaxel are presented to illustrate successful bioavailability enhancements. The article also highlights recent developments such as solid SEDDS (S-SEDDS), supersaturated SEDDS (Su-SEDDS), and polymer-assisted SEDDS. Future directions emphasize targeted delivery, patient compliance, and integration with nanomedicine approaches. This review aims to provide pharmaceutical scientists with a comprehensive resource on designing and deploying SEDDS to overcome solubility barriers in drug development. Formulation strategies focus on optimizing the ratio of oils, surfactants, and co-solvents to achieve stable emulsification and maximize drug loading. In vitro characterization typically involves assessing droplet size, zeta potential, and drug release profiles to predict in vivo performance. Additionally, in vivo studies evaluate pharmacokinetic parameters to confirm enhanced bioavailability and therapeutic efficacy.
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Sharma, R. K. & Mehta, A. P. (2025). Self-Emulsifying Drug Delivery System (SEDDS) for Enhancing Bioavailability of BCS Class II Drugs. International Journal of Science, Strategic Management and Technology, Volume 01(03), 1-9. https://doi.org/10.55041/ijsmt.v1i3.004
Sharma, Rohit, and Anjali Mehta. "Self-Emulsifying Drug Delivery System (SEDDS) for Enhancing Bioavailability of BCS Class II Drugs." International Journal of Science, Strategic Management and Technology, vol. Volume 01, no. 03, 2025, pp. 1-9. doi:https://doi.org/10.55041/ijsmt.v1i3.004.
Sharma, Rohit, and Anjali Mehta. "Self-Emulsifying Drug Delivery System (SEDDS) for Enhancing Bioavailability of BCS Class II Drugs." International Journal of Science, Strategic Management and Technology Volume 01, no. 03 (2025): 1-9. https://doi.org/https://doi.org/10.55041/ijsmt.v1i3.004.
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