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International Journal of Science, Strategic Management and Technology

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FORMULATION AND EVALUATION OF MUCOADHESIVE ORAL PATCHES FOR THE MANAGEMENT OF MOUTH ULCER

AUTHORS:
Divyani Jaiswal
Anubhav Shrivastav
Kavita savkare
Mentor
Affiliation
Thakur ShivKumar Singh Memorial Pharmacy College, Burhanpur
DOI: 10.55041/ijsmt.v2i5.196
CC BY 4.0 License:
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Abstract

Mucoadhesive buccal patches are widely recognized as an effective approach for delivering drugs directly to the oral mucosa for the treatment of mouth ulcers. The present investigation was undertaken to develop and evaluate mucoadhesive oral patches for improved management of oral ulcer conditions. The formulations were prepared by employing the solvent casting technique using suitable polymers, including Hydroxypropyl Methylcellulose (HPMC) and Carbopol, to obtain effective mucoadhesive and film-forming characteristics. OraTrust Gel was utilized as the therapeutic preparation to provide anti-inflammatory and pain-relieving activity. The prepared patches were evaluated for several physicochemical properties such as thickness, weight variation, folding endurance, surface pH, and visual appearance. The formulated films demonstrated satisfactory flexibility, uniform structure, and appropriate surface properties for buccal administration. The overall findings suggest that the developed mucoadhesive patches could enhance drug retention at the affected site, improve therapeutic response, and provide greater convenience and comfort to patients suffering from mouth ulcers.

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PUBLICATION DETAILS
Review Type:
Double-Blind Peer Review
License:
CC BY-NC 4.0
Volume/Issue:
Volume 02, Issue 05
Review Rounds:
2
Article Type:
Research Article
Publication Date:
May 12 2026
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Jaiswal, D., Shrivastav, A. & savkare, K. (2026). Formulation and Evaluation of Mucoadhesive Oral Patches for the Management of Mouth Ulcer. International Journal of Science, Strategic Management and Technology, 02(05). https://doi.org/10.55041/ijsmt.v2i5.196

Jaiswal, Divyani, et al.. "Formulation and Evaluation of Mucoadhesive Oral Patches for the Management of Mouth Ulcer." International Journal of Science, Strategic Management and Technology, vol. 02, no. 05, 2026, pp. . doi:https://doi.org/10.55041/ijsmt.v2i5.196.

Jaiswal, Divyani,Anubhav Shrivastav, and Kavita savkare. "Formulation and Evaluation of Mucoadhesive Oral Patches for the Management of Mouth Ulcer." International Journal of Science, Strategic Management and Technology 02, no. 05 (2026). https://doi.org/https://doi.org/10.55041/ijsmt.v2i5.196.

References
1.Ziyi Pan, Xu Zhang, Wangni Xie, Jing Cui, Yue Wang “Revisited and innovative perspectives of oral ulcer: from biological specificity to local treatment” Frontiers in Bioengineering and Biotechnology 2024.

2.Mohit and Md. Sadique Hussain “A brief review on buccal drug delivery system: advantages, limitations, and impact on healthcare system” World Journal of Pharmaceutical Research 2021.

3.Anu A. L, Prasobh G. R, Subash Chandran M. P, Juno S, Subodh S. Satheesh “A review on mucoadhesive bilayer buccal patches” World Journal of Pharmaceutical Research 2020.

4.Karande Trupti, Pawar Sanika, Kasabe Manisha, Korde Shweta “Pathophysiology of Mouth Ulcers” International Journal of Research Publication and Reviews 2025.

5.Shery Jacob, Anroop B. Nair, Jigar Shah, Sai H. S. Boddu, Bapi Gorain “An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery System” Multidisciplinary Digital Publishing Institute 2021

6.Sonal Jadhav, Isha Kanoj, Yashpal M. more “A review mucoadhesive buccal patches’’ World Journal of Pharmaceutical 2025.

7.Gitanjali a. chavan, Aarti s. tawani, Yogesh n. gavhane “Buccal Patches: A Promising Buccal Bio-adhesive Drug Delivery System - A Review” International Journal of Pharmacy and Pharmaceutical Research 2020.

8.Christina Viju John, Nisarga Arun Vavre, Shilpa Sampat Sawant, Abhishek Lalan Sharma, Kajal Shankar Shah and Shrutika Dipesh Patil “Oral mucoadhesive drug delivery system: Formulation strategies and evaluation techniques” World Journal of Advanced Research and Reviews  2024.

9.Lewis Shipp, Fang Liu, Laxmi Kerai-Varsani, Tochukwu C. Okwuosa “Buccal films: A review of therapeutic opportunities, formulations & relevant evaluation approaches” Journal of Controlled Release 2022.

10.Chinna Reddy P, Chaitanya K.S.C., Madhusudan Rao Y “A review on bio-adhesive buccal drug delivery systems: current status of formulation and evaluation methods” DARU Journal of Pharmaceutical Sciences Vol. 19, No.6 2011.
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✓ All ethical standards met
This article has undergone plagiarism screening and double-blind peer review. Editorial policies have been followed. Authors retain copyright under CC BY-NC 4.0 license. The research complies with ethical standards and institutional guidelines.
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