Inflammation is a complex biological response associated with numerous acute and chronic disorders, including neurodegenerative diseases. The present study investigates the anti-inflammatory potential of Moringa oleifera leaf extract using both acute and chronic experimental models. The evaluation was carried out using carrageenan-induced paw edema (acute inflammation), cotton pellet-induced granuloma, and formaldehyde-induced paw edema (chronic inflammation) in Swiss albino mice. Animals were treated with graded doses of Moringa oleifera extract (100, 200, 300, and 400 mg/kg), while standard drugs such as diclofenac sodium and indomethacin served as positive controls. Paw edema was measured using a digital plethysmometer, and percentage inhibition of inflammation was calculated. Biochemical analyses included the estimation of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), nitric oxide levels, prostaglandin E₂, and oxidative stress markers such as malondialdehyde, superoxide dismutase, catalase, and glutathione. Additionally, molecular markers associated with neuroinflammation, including NF-κB, COX-2, and iNOS expression, were assessed. The extract demonstrated significant dose-dependent inhibition of inflammation across all models, comparable to standard drugs.The findings suggest that Moringa oleifera possesses potent anti-inflammatory and antioxidant properties, supporting its potential therapeutic application in inflammatory and neurodegenerative disorders