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International Journal of Science, Strategic Management and Technology

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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF BUPROPION METFORMIN AND EMPAGLIFLOZIN BY RP-HPLC METHOD

AUTHORS:
Dr.GOPAL RAO.PAISA
B.INDU
M.KAVYA
M.SAIKRISHNA
Mentor
Affiliation
Svs school of pharmacy

HOD pharmaceutical Analysis
DOI: 10.55041/ijsmt.v2i7.079
CC BY 4.0 License:
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Abstract
A novel very rapid, sensitive, reverse phase High Performance Liquid Chromatography (RP-HPLC) technique was developed for the quantitative estimation of Bupropion in bulk and tablet dosage form. It was resolved by using a mobile phase Potassium di-hydrogen phosphate: methanol in the ratio (60:40 v/v) at a flow rate of 0.8mL/min. using UV - Visible detector at the wavelength of 228 nm for quantification. Efficient separation was achieved for Bupropion on used Waters Acquity HSS T-3 C18 (100 × 2.1 mm, 5μm). The retention time of Bupropion was 2.433min. The calibration graphs were linear and the method showed excellent recovery for tablet dosage form. The developed method was validated according to the International Conference on Harmonization (ICH) guidelines with respect to linearity, accuracy, precision, specificity and robustness.

 
Keywords
Bupropion HPLC new method development validation
Article Information
PUBLICATION DETAILS
Review Type:
Double-Blind Peer Review
License:
CC BY-NC 4.0
Volume/Issue:
Volume 02, Issue 7
Review Rounds:
2
Article Type:
Research Article
Publication Date:
Jul 14 2026
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RAO.PAISA, G., B.INDU, , M.KAVYA, & M.SAIKRISHNA, (2026). Analytical Method Development and Validation of Bupropion Metformin and Empagliflozin by RP-HPLC Method. International Journal of Science, Strategic Management and Technology, 02(7), 1-9. https://doi.org/10.55041/ijsmt.v2i7.079

RAO.PAISA, GOPAL, et al.. "Analytical Method Development and Validation of Bupropion Metformin and Empagliflozin by RP-HPLC Method." International Journal of Science, Strategic Management and Technology, vol. 02, no. 7, 2026, pp. 1-9. doi:https://doi.org/10.55041/ijsmt.v2i7.079.

RAO.PAISA, GOPAL, B.INDU, M.KAVYA, and M.SAIKRISHNA. "Analytical Method Development and Validation of Bupropion Metformin and Empagliflozin by RP-HPLC Method." International Journal of Science, Strategic Management and Technology 02, no. 7 (2026): 1-9. https://doi.org/https://doi.org/10.55041/ijsmt.v2i7.079.

References

  1. Lovekesh Mehta, and Jitender Singh.,RP-HPLC Method Development and Validation for the Determination of Bupropion Hydrochloride in a Solid Dosage Form.RRJPA: Volume 2  Issue 3  July – September, 2013,1-5

  2. A. Sameer Abdulaziz, K. Basavaiah; K. B. Vinay. . (2008). Titrimetric and spectrophotometric assay of bupropion hydrochloride in pharmaceuticals using mercury(II) nitrate.Anal. Chem. 80 (), 1756.

  3. Sevgi Tatar Ulu1 and Muzaffer Tuncel. (2012). Determination of Bupropion Using Liquid Chromatography with Fluorescence Detection in Pharmaceutical Preparations, Human Plasma and Human Urine. Journal of Chromatographic Science; 50:433–439.

Ethics and Compliance
✓ All ethical standards met
This article has undergone plagiarism screening and double-blind peer review. Editorial policies have been followed. Authors retain copyright under CC BY-NC 4.0 license. The research complies with ethical standards and institutional guidelines.
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