Butea monosperma is a medicinal plant everywhere recognized for its conventional use in wound management due to the existence of bioactive phytoconstituents such as flavonoids, tannins and phenolic compounds which exhibit antioxidant, antimicrobial activities and anti-inflammatory. However, the restorative application of these phytoconstituents in topical formulations is limited by poor aqueous solubility, low stability and inadequate penetration at the wound site. The present study was undertaken to design and optimize a polymer-based nanogel delivery system for Butea monosperma phytoconstituents with the aim of improving their wound healing performance. Phytoconstituents extracted from Butea monosperma were encapsulated into polymeric nanoparticles using a suitable formulation technique and subsequently incorporated into a nanogel matrix. Optimization of formulation variables was carried out to obtain a stable system with desirable nanoscale properties. The optimized nanogel was characterized for particle size, polydispersity index, zeta potential, entrapment efficiency, pH, viscosity and spreadability. In vitro drug release studies were performed to evaluate the release behaviour of phytoconstituents from the developed nanogel system. The formulated nanogel exhibited uniformly distributed nanosized particles with high entrapment efficiency, indicating effective federation of phytoconstituents within the polymeric network. Physicochemical evaluation revealed that the nanogel possessed suitable pH, viscosity and spreadability, making it significant for topical wound application. In vitro release studies demonstrated a sustained release profile of phytoconstituents from the nanogel compared to conventional gel formulations, which is advantageous for maintaining prolonged drug availability at the wound site. Additionally, the nanogel system enhanced the stability of the encapsulated phytoconstituents by protecting them from degradation. The observed formulation characteristics propose the potential of the polymer-based nanogel system to improve the topical delivery and therapeutic productiveness of Butea monosperma phytoconstituents in wound healing applications.