ULCERATIVE COLITIS AND ITS ADVANCED THERAPIES : A COMPREHENSIVE REVIEW
AUTHORS:
Mentor
Affiliation
Oriental College of Pharmacy, Sanpada, Navi Mumbai
DOI: 
SHARE THIS ARTICLE
CC BY 4.0 License:
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOWNLOAD ARTICLE
REVIEW REPORT
CITE THIS ARTICLE
Abstract
Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease (IBD) characterised by continuous mucosal inflammation of the large bowel, typically starting in the rectum and extending to varying degrees to the proximal colon. Ulcerative colitis significantly impairs the quality of life of affected patients, and forms a substantial component of global health care burden. The causes of ulcerative colitis are unknown, but considered to be multifactorial, including genetic predisposition, immune system dysfunction, environmental risk factors, and alterations in the normal colonic microbiota. In this review, we provide an in-depth analysis of current understanding of ulcerative colitis, including epidemiology, disease causes and mechanisms, pathophysiology, clinical features, diagnosis, current and emerging treatments, complications, and future management approaches.
Keywords
Ulcerative colitis inflammatory bowel disease pathogenesis diagnosis treatment biologics.
Article Information
PUBLICATION DETAILS
Review Type:
Double-Blind Peer Review
License:
CC BY-NC 4.0
Volume/Issue:
Volume 02, Issue 6
Review Rounds:
2
Article Type:
Research Article
Publication Date:
Jun 04 2026
Article Metrics
Article Views
67
PDF Downloads
7
HOW TO CITE
Copy
Pathak, S. A., Gupta, T. A. K., Gupta, N. A. K., Israr, A. A. M., Tank, D. R. & Adhe, R. S. (2026). Ulcerative Colitis and Its Advanced Therapies : A Comprehensive Review. International Journal of Science, Strategic Management and Technology, 02(6). https://doi.org/10.55041/ijsmt.v2i6.023
Pathak, Shivam, et al.. "Ulcerative Colitis and Its Advanced Therapies : A Comprehensive Review." International Journal of Science, Strategic Management and Technology, vol. 02, no. 6, 2026, pp. . doi:https://doi.org/10.55041/ijsmt.v2i6.023.
Pathak, Shivam,Taniya Gupta,Nilesh Gupta,Adnan Israr,Darpan Tank, and Rishikesh Adhe. "Ulcerative Colitis and Its Advanced Therapies : A Comprehensive Review." International Journal of Science, Strategic Management and Technology 02, no. 6 (2026). https://doi.org/https://doi.org/10.55041/ijsmt.v2i6.023.
References
- Colitis-Pathophysiology U. Inflammatory bowel disease part I: ulcerative colitis- pathophysiology and conventional and alternative treatment options. Altern Med Rev. 2003;8(3):247-83.
- Seidelin JB, Coskun M, Nielsen OH. Mucosal healing in ulcerative colitis: pathophysiology and pharmacology. Advances in clinical chemistry. 2013 Jan 1;59:101-23.
- Hindryckx P, Jairath V, D'haens G. Acute severe ulcerative colitis: from pathophysiology to clinical management. Nature Reviews Gastroenterology & Hepatology. 2016 Nov;13(11):654- 64.
- Miller C, Emmanuel A, Zarate-Lopez N, Taylor S, Bloom S. Constipation in ulcerative colitis: pathophysiology and practical management. Frontline Gastroenterology. 2021 Nov 1;12(6):493- 9.
- RIDER JA, MOELLER HC, PULETTI EJ, AGCAOILI LF, GIBBS JO, DEVEREAUX RG,
- SWADER J, STEVENSON E. Ulcerative Colitis: Pathophysiology, Diagnosis, and Treatment. Archives of Surgery. 1961 Aug 1;83(2):181-9.
- Holtmann MH, Galle PR. Current concept of pathophysiological understanding and natural course of ulcerative colitis. Langenbeck's Archives of Surgery. 2004 Oct;389(5):341-9.
- Hanauer SB. Update on the etiology, pathogenesis and diagnosis of ulcerative colitis. Nature clinical practice Gastroenterology & hepatology. 2004 Nov 1;1(1):26-31.
- Colitis-Pathophysiology U. Inflammatory bowel disease part I: ulcerative colitis-pathophysiology and conventional and alternative treatment options. Altern Med Rev. 2003;8(3):247-83.
- Hanzel J, Hulshoff MS, Grootjans J, D’Haens G. Emerging therapies for ulcerative colitis. Expert
- Review of Clinical Immunology. 2022 May 4;18(5):513-24.
- Wehkamp J, Stange EF. Recent advances and emerging therapies in the non-surgical management of ulcerative colitis. F1000Research. 2018 Aug 7;7:F1000-aculty.
- Wangchuk P, Yeshi K, Loukas A. Ulcerative colitis: clinical biomarkers, therapeutic targets, and emerging treatments. Trends in pharmacological sciences. 2024 Oct 1;45(10):892-903.
- Bretto E, Ribaldone DG, Caviglia GP, Saracco GM, Bugianesi E, Frara S. Inflammatory bowel disease: emerging therapies and future treatment strategies. Biomedicines. 2023 Aug 11;11(8):2249.
- AlAmeel T, AlMutairdi A, Al-Bawardy B. Emerging therapies for ulcerative colitis: updates from recent clinical trials. Clinical and experimental gastroenterology. 2023 Dec 31:147-67.
Ethics and Compliance
✓ All ethical standards met
This article has undergone plagiarism screening and double-blind peer review. Editorial policies have been followed. Authors retain copyright under CC BY-NC 4.0 license. The research complies with ethical standards and institutional guidelines.
Indexed In
Similar Articles
An Intelligent Mental Health Tracker Based on Social Media Activity
(2026)
DOI: 10.55041/ijsmt.v2i3.211
Lean Tools Application to Minimize Construction Waste and Improve Site Productivity: A Case Study on 5S System and Last Planner System
(2026)
DOI: 10.55041/ijsmt.v2i5.090
A Novel Approach to Modelling Anisotropic Rock Deformation using Hyperbolic Stress-Strain Relationship
(2026)
DOI: 10.55041/ijsmt.v2i2.012
Previous Article